Middleware was introduced to facilitate the development of sophisticated applications based on a uniform methodology and industry standards. However, early research and practice suggested that no one-size-fits-all approach was suitable for all application domains and scenarios. This gave rise to industry initiatives to standardize domain-specific middleware services and profiles, as well as research efforts on configurable, reflective, and adaptive middleware. The industry’s approach led to easy deployment, although with a level of flexibility limited by the extent of existing profiles. The approach of the research community, on the other hand, enabled high flexibility, allowing any middleware configuration to be defined. Nevertheless, creating sound configurations using this approach is a challenging task, limiting the target audience to expert engineers. As a consequence, both initiatives do not scale with the current proliferation of specialized application domains. In this paper, we target this problem with an approach that leverages model-driven engineering for the construction of domain-specific middleware platforms. A set of high-level, yet expressive, building blocks is defined in the form of a metamodel, which is used to create models that specify the desired middleware configuration. We argue that this approach enables the rapid development of middleware platforms to match the proliferation of application domains, at the same time as it does not require per-application middleware construction or even highly skilled middleware engineers. We present the current state of our research and discuss research directions to fully realize the approach.